See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PTEN (human recombinant)

Cayman Chemical Item Number 10009746

TEP1; Phosphatidylinositol 3-phosphatase; MMAC1; Phosphatase and Tensin Homology on Chromosome 10

See more

Description

Source: human recombinant N-terminal hexahistidine-tagged protein purified from Sf21 cells · Mr: 50.8 kDa · Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP3). PTEN interacts with many other proteins to regulate cell division and migration, as well as promoting apoptosis when necessary.1 Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma, making PTEN an important tumor suppressor.2,3 PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.4

1 Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

2 Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

3 Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7 115-129 (2000).

4 Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15 356-362 (1997).

Synonyms
  • TEP1
  • Phosphatidylinositol 3-phosphatase
  • MMAC1
  • Phosphatase and Tensin Homology on Chromosome 10
Formulation 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
Purity ≥95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15 356-362 (1997).

Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7 115-129 (2000).

Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

Show all 4 Hide all but first 3
Size Price Quantity Subtotal
25 µg $153.00 $0.00
50 µg $291.00 $0.00
100 µg $551.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Akt (human recombinant) Western Ready Control Exclusive
PtdIns-(4,5)-P2-biotin (sodium salt)
PTEN Blocking Peptide
PTEN Polyclonal Antibody
PTEN Western Ready Control
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?