PTEN Western Ready Control

Cayman Chemical Item Number 10009747

TEP1; MMAC1; Phosphatidylinositol 3-phosphatase; Phosphatase and Tensin Homology on Chromosome 10

Description

Application(s): positive control for WB · M_r: 84 kDa (GST fusion) · PTEN dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP₃) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.¹ PTEN interacts with many other proteins to regulate cell division and migration as well as promoting apoptosis when necessary.² Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma.^3,4

1 Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15 356-362 (1997).

2 Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

3 Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

4 missing reference text

Synonyms

TEP1
MMAC1
Phosphatidylinositol 3-phosphatase
Phosphatase and Tensin Homology on Chromosome 10

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15 356-362 (1997).

Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7 115-129 (2000).

Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

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