Cayman Chemical | ApoA1 Western Ready Control | Description • Apolipoprotein A1

10009751 ApoA1 Western Ready Control

Apolipoprotein A₁

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• See more Western Blot; Proteins; Recombinant Proteins; Western Ready Control; Atherosclerosis

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Application(s): positive control for WB · Source: human recombinant protein · M_r: 28 kDa · ApoA1 is a major protein component in high-density lipoproteins (HDL). It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues and transports cholesterol to the liver and other tissues for excretion and steroidogenesis.¹ Serum ApoA1 levels are inversely related to the risk of developing atherosclerosis.² Loss-of-function mutations in ApoA1 are causes of diseases such as HDL deficiency type 1 (or Tangier disease) and type 2 (familial hypoalphalipoproteinemia), and systemic non-neuropathic amyloidosis. ^3,4 Liver and small intestine are two main sources of the protein.

1 Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., et al. Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases. Proc Natl Acad Sci USA 103(7) 2126-2131 (2006).

2 Haas, M.J., Reinacher, D., Li, J.P., et al. Regulation of apoA1 gene expression with acidosis: Requirement for a transcriptional repressor. J Mol Endocrinol 27 43-57 (2001).

3 Tall, A.R., Wang, N. Tangier disease as a test of the reverse cholesterol transport hypothesis. J Clin Invest 106(10) 1205-1207 (2000).

4 Cheung, M.C., Mendez, A.J., Wolf, A.C., et al. Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling tangier disease and their effects on intracellular cholesterol efflux. J Clin Invest 91 522-529 (1993).

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Purchase 10009751 ApoA1 Western Ready Control

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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