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NMDA Receptor NR2B Subunit (Phospho-Tyr1252) Polyclonal Antibody

Cayman Chemical Item Number 10009759

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Formulation Peptide affinity-purified antibody
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
human NMDA receptor +
rat NMDA receptor +
bovine NMDA receptor (expected) +
canine NMDA receptor (expected) +
chicken NMDA receptor (expected) +
murine NMDA receptor (expected) +
non-human primates NMDA receptor (expected) +
zebrafish NMDA receptor (expected) +
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Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding the Phospho-Tyr1252 of human NMDA Receptor NR2B Subunit · Host: rabbit · Application(s): WB · The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development, and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy, and ischemic neuronal death. 1,2,3 The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. 4 Phosphorylation of Tyr1252 in NR2B is thought to potentiate NMDA receptor-dependent influx of calcium.5

1 Grosshans, D.R. LTP leads to rapid surface expression of NMDA but not AMA receptors in adult rat CA1. Nat Neurosci 5 27-33 (2002).

2 Wenthold, R.J., Prybylowski, K., Standley, S., et al. Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43 335-358 (2003).

3 Carroll, R.C., Zukin, R.S. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25 571-577 (2002).

4 Ishii, T., Moriyoshi, K., Sugihara, H., et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268(4) 2836-2843 (1993).

5 Takasu, M.A., Dalva, M.B., Zigmond, R.E., et al. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB Receptors. Science 295 491-495 (2002).

Related Articles

Ishii, T., Moriyoshi, K., Sugihara, H., et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268(4) 2836-2843 (1993).

Grosshans, D.R. LTP leads to rapid surface expression of NMDA but not AMA receptors in adult rat CA1. Nat Neurosci 5 27-33 (2002).

Wenthold, R.J., Prybylowski, K., Standley, S., et al. Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43 335-358 (2003).

Takasu, M.A., Dalva, M.B., Zigmond, R.E., et al. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB Receptors. Science 295 491-495 (2002).

Carroll, R.C., Zukin, R.S. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25 571-577 (2002).

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Pricing updated 2010-09-06. Prices are subject to change without notice.

Pricing is for North America only. Other customers should contact a distributor in their region.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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