Cayman Chemical | NMDA Receptor NR2B Subunit (Phospho-Tyr1336) Polyclonal Antibody

10009760 NMDA Receptor NR2B Subunit (Phospho-Tyr¹³³⁶) Polyclonal Antibody

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Antigen: phosphopeptide corresponding to amino acid residues surrounding the Phospho-Tyr¹³³⁶ of human NMDA Receptor NR2B Subunit · Host: rabbit · Application(s): WB · The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development, and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy, and ischemic neuronal death. ^1,2,3 The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. ⁴ Phosphorylation of Tyr¹³³⁶ in NR2B is thought to potentiate NMDA receptor-dependent influx of calcium.⁵ Ischemia may also increase the phosphorylation of this site.

1 Grosshans, D.R. LTP leads to rapid surface expression of NMDA but not AMA receptors in adult rat CA1. Nat Neurosci 5 27-33 (2002).

2 Wenthold, R.J., Prybylowski, K., Standley, S., et al. Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43 335-358 (2003).

3 Carroll, R.C., Zukin, R.S. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25 571-577 (2002).

4 Ishii, T., Moriyoshi, K., Sugihara, H., et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268(4) 2836-2843 (1993).

5 Takasu, M.A., Dalva, M.B., Zigmond, R.E., et al. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB Receptors. Science 295 491-495 (2002).

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Pricing updated 2010-03-19.
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