See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10591 Exclusive

Cayman Chemical Item Number 10009797

Sirtuin 1 Activator 3; SIRT1 Activator 3 (CAS 839699-72-8)

CAY10591 (CAS 839699-72-8)

See more

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This compound increases fluorescence by 233% in a SIRT1 activity assay.1 [Activator activity was defined as the percentage of signal increase relative to signal window in the following formula: 100 x (Sample - Signallow)/(Signalhigh - Signallow)]. CAY10591 suppresses TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 pg/ml (control) to 104 and 53 pg/ml with 20 and 60 µM CAY10591, respectively. This activator also has a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which would indicate the potential of SIRT1 activators for anti-obesity or anti-diabetic purposes.1

1 Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).

Synonyms
  • Sirtuin 1 Activator 3
  • SIRT1 Activator 3
Formal Name 2-​amino-​N-​cyclopentyl-​1-​(3-​methoxypropyl)-​1H-​pyrrolo[2,​3-​b]quinoxaline-​3-​carboxamide
CAS Number 839699-72-8
Molecular Formula C20H25N5O2
Formula Weight 367.5
Formulation A crystalline solid
Purity >98%
λmax 224, 263, 394, 414 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
COCCCn1c2nc3ccccc3nc2c(C(=O)​NC2CCCC2)​c1N=N

Background Reading

Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).
Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
25 mg $893.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

A-922500
CAY10433
HDAC1 (human recombinant)
HDAC1 Inhibitor Screening Assay Kit
HDAC2 (human recombinant)
HDAC3/NCOR2 (human recombinant)
HDAC5 (human recombinant)
HDAC6 (human recombinant)
HDAC9 (human recombinant)
HDAC Activity Assay Kit
JGB1741 Exclusive
SIRT1 Direct Fluorescent Screening Assay Kit
SIRT1 FRET-Based Screening Assay Kit
trans-Resveratrol
Tubastatin A (trifluoroacetate salt) Exclusive
Show all 15 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?