Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

EX-527

Cayman Chemical Item Number 10009798

(CAS 49843-98-3)

EX-527 (CAS 49843-98-3)

See more	Inhibitors (493) Cell Biology (281) Epigenetics (175) Gene Regulation (173) Inflammation (383) Metabolism (139)

Description

Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC₅₀ = 98 nM).¹ It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.²

1 Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).

2 Solomon, J.M., Pasupuleti, R., Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26(1) 28-38 (2006).

Formal Name	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
CAS Number	49843-98-3
Molecular Formula	C₁₃H₁₃ClN₂O
Formula Weight	248.7
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21

Background Reading

Huhtiniemi, T., Suuronen, T., Rinne, V.M., et al. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors. J Med Chem 51 4377-4380 (2008).

Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).

Solomon, J.M., Pasupuleti, R., Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26(1) 28-38 (2006).

EX-527 is available in the following screening library:

Epigenetics Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$17.00		$0.00
5 mg	$77.00		$0.00
10 mg	$136.00		$0.00
25 mg	$298.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

AGK2

SIRT1 Direct Fluorescent Screening Assay Kit

SIRT1 FRET-Based Screening Assay Kit

SIRT1 (human recombinant)

trans-Resveratrol

Show all 9 Hide all but first 3

Downloads

	Download Product Insert 105 Kb PDF
	Download Material Safety Data Sheet (MSDS) 23 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640