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1-Stearoyl-2-Arachidonoyl PC

Cayman Chemical Item Number 10009864

1-Stearoyl-2-Arachidonoyl-Phosphatidylcholine; SAPC (CAS 35418-59-8)

1-Stearoyl-2-Arachidonoyl PC (CAS 35418-59-8)

See more	Phospholipids (61)

Description

Phosphatidylcholine species are a common class of phospholipids that comprise the mammalian cell membrane. 1-Stearoyl-2-arachidonoyl phosphatidylcholine (SAPC) is an important source of activation-induced arachidonate released as a substrate for cyclooxygenase (COX-2) mediated signaling. It is the preferred substrate for the 85 kDa cytosolic phospholipase, which translocates to endoplasmic and nuclear membranes in response to the activation-induced rise in intracellular calcium.¹ The arachidonate thus liberated can be utilized by either COX or lipoxygenase enzymes for the elaboration of further eicosanoid mediators.

1 Bittova, L., Sumandea, M., and Cho, W. A structure-function study of the C₂ domain of cytosolic phospholipase A₂. Identification of essential calcium ligands and hydrophobic membrane binding residues. J Biol Chem 274 9665-9672 (1999).

Synonyms	1-Stearoyl-2-Arachidonoyl-Phosphatidylcholine SAPC
Formal Name	1-ocatadeconyl-2R-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glyceryl-3-phosphorylcholine
CAS Number	35418-59-8
Molecular Formula	C₄₆H₈₄NO₈P
Formula Weight	810.1
Formulation	A solution in ethanol
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)OC(=O)CCC/C=C\C/C=C\C\C(=C/C/C=C\CCCCC)\C

Background Reading

Bittova, L., Sumandea, M., and Cho, W. A structure-function study of the C₂ domain of cytosolic phospholipase A₂. Identification of essential calcium ligands and hydrophobic membrane binding residues. J Biol Chem 274 9665-9672 (1999).

1-Stearoyl-2-Arachidonoyl PC is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$9.00		$0.00
5 mg	$41.00		$0.00
10 mg	$72.00		$0.00
25 mg	$158.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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