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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

GW 590735 Exclusive

Cayman Chemical Item Number 10009880

(CAS 622402-22-6)

GW 590735 (CAS 622402-22-6)

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Description

The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.1 GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression of a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1

1 Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

Formal Name 2-​methyl-​2-​(4-​((4-​methyl-​2-​(4-​(trifluoromethyl)phenyl)thiazole-​5-​carboxamido)methyl)phenoxy)propanoic acid
CAS Number 622402-22-6
Molecular Formula C23H21F3N2O4S
Formula Weight 478.5
Formulation A crystalline solid
Purity ≥98%
λmax 224, 311 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NCc1ccc(cc1)​OC(C)​(C)​C(=O)​O)​c1sc(nc1C)​c1ccc(cc1)​C(F)​(F)​F

Background Reading

Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

GW 590735 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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