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GW 590735 Exclusive

Cayman Chemical Item Number 10009880

(CAS 622402-22-6)

GW 590735 (CAS 622402-22-6)

See more	Lipid Mediators (47) Lipids (167) PPAR (59) Angiogenesis (29) Atherosclerosis (323) Endocrinology (335) Metabolism (139)

Description

The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.¹ GW 590735 is a potent and selective agonist of PPARα with an EC₅₀ value of 4 nM for the expression of a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.¹

1 Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

Formal Name	2-methyl-2-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid
CAS Number	622402-22-6
Molecular Formula	C₂₃H₂₁F₃N₂O₄S
Formula Weight	478.5
Formulation	A crystalline solid
Purity	≥98%
λ_max	224, 311 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(NCc1ccc(cc1)OC(C)(C)C(=O)O)c1sc(nc1C)c1ccc(cc1)C(F)(F)F

Background Reading

Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

GW 590735 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$43.00		$0.00
5 mg	$194.00		$0.00
10 mg	$344.00		$0.00
25 mg	$753.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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