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SAHA

Cayman Chemical Item Number 10009929

Vorinostat; Suberoylanilide Hydroxamic Acid; Zolinza™ (CAS 149647-78-9)

SAHA (CAS 149647-78-9)

See more	Histone Deacetylase (12) Inhibitors (493) Cancer (606) Epigenetics (175) Histone Modification (126)

Description

SAHA (suberoylanilide hydroxamic acid, Vorinostat, Zolinza^™) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I and class II HDACs at around 50 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.¹ SAHA is currently in advanced clinical trials for the treatment of cancer.

1 Marks, P.A., and Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotech 25(1) 84-90 (2007).

Synonyms	Vorinostat Suberoylanilide Hydroxamic Acid Zolinza™
Formal Name	N1-hydroxy-N8-phenyl-octanediamide
CAS Number	149647-78-9
Molecular Formula	C₁₄H₂₀N₂O₃
Formula Weight	264.3
Formulation	A crystalline solid
Purity	>98%
λ_max	243 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ONC(=O)CCCCCCC(=O)Nc1ccccc1

Background Reading

Marks, P.A., and Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotech 25(1) 84-90 (2007).

SAHA is available in the following screening libraries:

Size	Price	Quantity	Subtotal
50 mg	$40.00		$0.00
100 mg	$76.00		$0.00
250 mg	$180.00		$0.00
500 mg	$320.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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