Application(s): positive control for WB · Source: human recombinant protein · M_r: 35 kDa · Erythropietin (EPO) is a glycoprotein hormone that is the primary regulator of erythropoiesis, maintaining the body’s red blood cell mass at an optimum level.^1,2 In response to a decrease in tissue oxygenation, EPO protein levels are upregulated in the kidney. The secreted hormone binds to specific receptors on the surface of red blood cell precursors in the bone marrow, leading to their survival, proliferation, differentiation, and ultimately to an increase in hematocrit.¹

1 Egrie, J.C., and Browne, J.K. Development and characterization of novel erythropoiesis stimulating protein (NESP). Br J Cancer 84(1) 3-10 (2001).

2 Broudy, V.C., Tait, J.F., and Powell, J.S. Recombinant human erythropoietin: Purification and analysis of carbohydrate linkage. Arch Biochem Biophys 265(2) 329-336 (1988).

Broudy, V.C., Tait, J.F., and Powell, J.S. Recombinant human erythropoietin: Purification and analysis of carbohydrate linkage. Arch Biochem Biophys 265(2) 329-336 (1988).

Egrie, J.C., and Browne, J.K. Development and characterization of novel erythropoiesis stimulating protein (NESP). Br J Cancer 84(1) 3-10 (2001).