Zeaxanthin is one of the two diet-obtained carotenoids present in the macula region of the eye. High dietary intake of zeaxanthin correlates with reduced risk of advanced neovascular age-related macular degeneration.1,2 In a rodent model, zeaxanthin directly inhibits oxidative damage and the production of VEGF and adhesion molecules induced by diabetes.3
1
SanGiovanni, J.P., Chew, E.Y., Clemons, T.E., et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age related macular degeneration in a case-control study. Arch Ophthalmol125(9)1225-1232(2007).
2
Landrum, J.T., and Bone, R.A. Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys385(1)28-40(2001).
3
Hammond, B.R. Jr. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev66(12)695-702(2008).
Hammond, B.R. Jr. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev66(12)695-702(2008).
Landrum, J.T., and Bone, R.A. Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys385(1)28-40(2001).
SanGiovanni, J.P., Chew, E.Y., Clemons, T.E., et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age related macular degeneration in a case-control study. Arch Ophthalmol125(9)1225-1232(2007).
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