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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)12(13)-EpOME-d4

Cayman Chemical Item Number 10009996

iso-Leukotoxin-d4; 12,13-EODE-d4

(±)12(13)-EpOME-d4

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Description

(±)12(13)-EpOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry (MS). (±)12(13)-EpOME is the 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst.1 The toxicity and biosynthesis of (±)12(13)-EpOME have not been well differentiated from (±)12(13)-EpOME, but have been presumed to be essentially the same.2 (±)9(10)-EpOME is generated by neutrophils during the oxidative burst.1 It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome.2

1 Hayakawa, M., Sugiyama, S., Takamura, T., et al. Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoate. Biochem Biophys Res Commun 137 424-430 (1986).

2 Ozawa, T., Hayakawa, M., Takamura, T., et al. Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia. Biochem Biophys Res Commun 134 1071-1078 (1986).

Synonyms
  • iso-Leukotoxin-d4
  • 12,13-EODE-d4
Formal Name (±)12(13)epoxy-​9Z-​octadecenoic-​9,​10,​12,​13-​d4 acid
Molecular Formula C18H28D4O3
Formula Weight 300.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d4)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@@H]​1([2H]​)​O[C@@H]​1([2H]​)​C\C(=C(\[2H]​)​/CCCCCCCC(=O)​O)​\[2H]​

Background Reading

Ozawa, T., Hayakawa, M., Takamura, T., et al. Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia. Biochem Biophys Res Commun 134 1071-1078 (1986).

Hayakawa, M., Sugiyama, S., Takamura, T., et al. Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoate. Biochem Biophys Res Commun 137 424-430 (1986).
Size Price Quantity Subtotal
25 µg $91.00 $0.00
50 µg $171.00 $0.00
100 µg $324.00 $0.00
250 µg $720.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(±)12(13)-EpOME
(±)9(10)-EpOME
(±)9(10)-EpOME-d4

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