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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

(±)8,9-DHET-d11 Exclusive

Cayman Chemical Item Number 10009998

(±)8,9-DiHETrE-d11

(±)8,9-DHET-d11

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Description

(±)8,9-DiHETrE-d11 contains 11 deuterium atoms at the 16, 16, 17, 17, 18, 18, 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8,9-DiHETrE by GC- or LC-mass spectrometry. Epoxide hydrolases convert the EpETrEs into vicinal diols, with the concurrent loss of much of their biological activity.1 The 8(S),9(R)-EpETrE isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.2

1 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

2 Zhang, J.Y., Prakash, C., Yamashita, K., et al. Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase. Biochem Biophys Res Commun 183 138-143 (1992).

Synonyms
  • (±)8,9-DiHETrE-d11
Formal Name (±)8,​9-​dihydroxy-​5Z,​11Z,​14Z-​eicosatrienoic-​16,​16,​17,​17,​18,​18,​19,​19,​20,​20,​20-​d11 acid
Molecular Formula C20H33D11O4
Formula Weight 349.6
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d11)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\CC(O)​C(O)​C/C=C\CCCC(=O)​O

Background Reading

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

Zhang, J.Y., Prakash, C., Yamashita, K., et al. Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase. Biochem Biophys Res Commun 183 138-143 (1992).

Size Price Quantity Subtotal
25 µg $148.00 $0.00
50 µg $281.00 $0.00
100 µg $533.00 $0.00
250 µg $1,184.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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(±)8,9-DHET

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Batch-specific Information

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FAQs

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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