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10009999 5(Z),11(Z),14(Z)-Eicosatrienoic Acid
Sciadonic Acid; 5,11,14,20:3
(CAS 7019-85-4)
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5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods.1,2,3 A diet containing MPSO lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.1 5(Z),11(Z),14(Z)-Eicosatrienoic acid methyl ester, when topically applied, reduces inflammatory processes, potentially by displacing arachidonic acid from phospholipid pools and reducing downstream inflammatory products such as prostaglandin E2 and leukotrienes.4
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1
Asset, G., Leroy, A., Bauge, E., et al. Effects of dietary maritime pine (Pinus pinaster)-seed oil on high-density lipoprotein levels and in vitro cholesterol efflux in mice expressing human apolipoprotein A-I. British Journal of Nutrition 84 353-360 (2000).
2
Mongrand, S., Badoc, A., Patouille, B., et al. Taxonomy of gymnospermae: Multivariate analyses of leaf fatty acid composition. Phytochem 58 101-115 (2001).
3
Go, J.V., Rezanka, T., Srebnik, M., et al. Variability of fatty acid components of murine and freshwater gastropod speices from the littoral zone of the Red Sea, Mediterranean Sea, and Sea of Galilee. Biochemical Systematics and Ecology 30 819-835 (2002).
4
Berger, A., Monnard, I., Baur, M., et al. Epidermal anti-inflammatory properties of 5,11,14 20:3: Effects on mouse ear edema, PGE2 levels in cultured keratinocytes, and PPAR activation. Lipids in Health and Disease 1(5) 1-12 (2002).
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Pricing updated 2010-03-13.
Prices are subject to change without notice.
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