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5(Z),11(Z),14(Z)-Eicosatrienoic Acid

Cayman Chemical Item Number 10009999

Sciadonic Acid; 5,11,14,20:3 (CAS 7019-85-4)

5(Z),11(Z),14(Z)-Eicosatrienoic Acid (CAS 7019-85-4)

See more	Fatty Acids (267) Inflammation (383)

Description

5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods.^1,2,3 A diet containing MPSO lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.¹ 5(Z),11(Z),14(Z)-Eicosatrienoic acid methyl ester, when topically applied, reduces inflammatory processes, potentially by displacing arachidonic acid from phospholipid pools and reducing downstream inflammatory products such as prostaglandin E₂ and leukotrienes.⁴

1 Asset, G., Leroy, A., Bauge, E., et al. Effects of dietary maritime pine (Pinus pinaster)-seed oil on high-density lipoprotein levels and in vitro cholesterol efflux in mice expressing human apolipoprotein A-I. Br J Nutr 84 353-360 (2000).

2 Mongrand, S., Badoc, A., Patouille, B., et al. Taxonomy of gymnospermae: Multivariate analyses of leaf fatty acid composition. Phytochem 58 101-115 (2001).

3 Go, J.V., Rezanka, T., Srebnik, M., et al. Variability of fatty acid components of murine and freshwater gastropod speices from the littoral zone of the Red Sea, Mediterranean Sea, and Sea of Galilee. Biochem Syst Ecol 30 819-835 (2002).

4 Berger, A., Monnard, I., Baur, M., et al. Epidermal anti-inflammatory properties of 5,11,14 20:3: Effects on mouse ear edema, PGE₂ levels in cultured keratinocytes, and PPAR activation. Lipids Health Dis 1(5) 1-12 (2002).

Synonyms	Sciadonic Acid 5,11,14,20:3
Formal Name	5Z,11Z,14Z-eicosatrienoic acid
CAS Number	7019-85-4
Molecular Formula	C₂₀H₃₄O₂
Formula Weight	306.5
Formulation	A solution in ethanol
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\CCCC/C=C\CCCC(=O)O

Background Reading

Asset, G., Leroy, A., Bauge, E., et al. Effects of dietary maritime pine (Pinus pinaster)-seed oil on high-density lipoprotein levels and in vitro cholesterol efflux in mice expressing human apolipoprotein A-I. Br J Nutr 84 353-360 (2000).

Berger, A., Monnard, I., Baur, M., et al. Epidermal anti-inflammatory properties of 5,11,14 20:3: Effects on mouse ear edema, PGE₂ levels in cultured keratinocytes, and PPAR activation. Lipids Health Dis 1(5) 1-12 (2002).

Go, J.V., Rezanka, T., Srebnik, M., et al. Variability of fatty acid components of murine and freshwater gastropod speices from the littoral zone of the Red Sea, Mediterranean Sea, and Sea of Galilee. Biochem Syst Ecol 30 819-835 (2002).

Mongrand, S., Badoc, A., Patouille, B., et al. Taxonomy of gymnospermae: Multivariate analyses of leaf fatty acid composition. Phytochem 58 101-115 (2001).

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5(Z),11(Z),14(Z)-Eicosatrienoic Acid is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 µg	$45.00		$0.00
500 µg	$203.00		$0.00
1 mg	$360.00		$0.00
5 mg	$1,575.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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