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LY223982 Exclusive

Cayman Chemical Item Number 10010024

SKF 107324; CGS 23131 (CAS 117423-74-2)

LY223982 (CAS 117423-74-2)

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Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM.1 LY223982 inhibits the LTB4-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively.2 However, concentrations of LY223982 up to 10 µM do not inhibit binding of LTB4 to human BLT1 or BLT2 expressed in CHO cells.3

1 Gapinski, D.M., Mallett, B.E., Froelich, L.L., et al. Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain. J Med Chem 33 2807-2813 (1990).

2 Jackson, W.T., Boyd, R.J., Froelich, L.L., et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther 263(3) 1009-1014 (1992).

3 Yokomizo, T., Kato, K., Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem 276(15) 12454-12459 (2001).

Synonyms
  • SKF 107324
  • CGS 23131
Formal Name 5-​(3-​carboxybenzoyl)-​2-​[[(5E)-​6-​(4-​methoxyphenyl)-​5-​hexenyl]oxy]-​benzenepropanoic acid
CAS Number 117423-74-2
Molecular Formula C30H30O7
Formula Weight 502.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(/C=C\CCCCOc2ccc(cc2CCC(=O)​O)​C(=O)​c2cccc(c2)​C(=O)​O)​cc1

Background Reading

Gapinski, D.M., Mallett, B.E., Froelich, L.L., et al. Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain. J Med Chem 33 2807-2813 (1990).

Jackson, W.T., Boyd, R.J., Froelich, L.L., et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther 263(3) 1009-1014 (1992).

Yokomizo, T., Kato, K., Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem 276(15) 12454-12459 (2001).
Size Price Quantity Subtotal
1 mg $21.00 $0.00
5 mg $95.00 $0.00
10 mg $168.00 $0.00
25 mg $368.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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