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CAY10570 Exclusive

Cayman Chemical Item Number 10010032

(CAS 875014-22-5)

CAY10570 (CAS 875014-22-5)

See more	Inhibitors (493) Endocrinology (335) Inflammation (383) Metabolism (139) Neuroscience (651) Pain (144) Parkinson's Research (18)

Description

The enzyme fatty acid amide hydrolase (FAAH) is capable of hydrolyzing and inactivating anandamide (AEA) and other fatty acid amides that act as agonists for the central cannabinoid (CB₁) receptor.¹ CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC₅₀ value of 1.3 µM.² CAY10570 has no affinity for the human CB₁ receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed by the enzyme.²

1 Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

2 Muccioli, G.G., Fazio, N., Scriba, G.K.E., et al. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. J Med Chem 49 417-425 (2006).

Formal Name	3-decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone
CAS Number	875014-22-5
Molecular Formula	C₂₅H₃₂N₂OS
Formula Weight	408.6
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCN1C(=S)NC(c2ccccc2)(c2ccccc2)C1=O

Background Reading

Muccioli, G.G., Fazio, N., Scriba, G.K.E., et al. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. J Med Chem 49 417-425 (2006).

Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

Size	Price	Quantity	Subtotal
500 µg	$23.00		$0.00
1 mg	$44.00		$0.00
5 mg	$184.00		$0.00
10 mg	$322.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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