Cayman Chemical | CAY10570 | Description (CAS 875014-22-5)

10010032 CAY10570

(CAS 875014-22-5)

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The enzyme fatty acid amide hydrolase (FAAH) is capable of hydrolyzing and inactivating anandamide (AEA) and other fatty acid amides that act as agonists for the central cannabinoid (CB₁) receptor.¹ CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC₅₀ value of 1.3 µM.² CAY10570 has no affinity for the human CB₁ receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed by the enzyme.²

1 Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

2 Muccioli, G.G., Fazio, N., Scriba, G.K.E., et al. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. J Med Chem 49 417-425 (2006).

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Pricing updated 2010-03-15.
Prices are subject to change without notice.

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·	2-Acetyl-5-tetrahydroxybutyl Imidazole
·	FABP2 (human recombinant)
·	CAY10570

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