10010032 CAY10570
(CAS 875014-22-5)
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The enzyme fatty acid amide hydrolase (FAAH) is capable of hydrolyzing and inactivating anandamide (AEA) and other fatty acid amides that act as agonists for the central cannabinoid (CB1) receptor.1 CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC50 value of 1.3 µM.2 CAY10570 has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed by the enzyme.2
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1
Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).
2
Muccioli, G.G., Fazio, N., Scriba, G.K.E., et al. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. J Med Chem 49 417-425 (2006).
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Pricing updated 2010-03-15.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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