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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10561 Exclusive

Cayman Chemical Item Number 10010043

Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4)

CAY10561 (CAS 933786-58-4)

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Description

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary.1 CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM).2 This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM).2 CAY10561 inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.2

1 Junttila, M.R., Li, S., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008).

2 Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of selective pyrazolylpyrrole ERK inhibitors. J Med Chem 50 1280-1287 (2007).

Synonyms
  • Pyrazolylpyrrole ERK Inhibitor
Formal Name N-​[1-​(3-​chloro-​4-​fluorophenyl)-​2-​hydroxyethyl]-​4-​[4-​(3-​chlorophenyl)-​1H-​pyrazol-​3-​yl]-​1H-​pyrrole-​2-​carboxamide
CAS Number 933786-58-4
Molecular Formula C22H17Cl2FN4O2
Formula Weight 459.3
Formulation A crystalline solid
Purity >98%
λmax 270 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OCC(NC(=O)​c1[nH]​cc(c1)​c1[nH]​ncc1c1cccc(Cl)​c1)​c1ccc(F)​c(Cl)​c1

Background Reading

Junttila, M.R., Li, S., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008).

Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of selective pyrazolylpyrrole ERK inhibitors. J Med Chem 50 1280-1287 (2007).

CAY10561 is available in the following screening library:

Size Price Quantity Subtotal
500 µg $20.00 $0.00
1 mg $38.00 $0.00
5 mg $160.00 $0.00
10 mg $280.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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