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PAF Acetylhydrolase (human) Western Ready Control

Cayman Chemical Item Number 10010081

PAF-AH; Lp-PLA2; Platelet-activating Factor Acetylhydrolase; Lipoprotein PLA2

PAF Acetylhydrolase (human) Western Ready Control

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Description

Application(s): positive control for WB · Source: human recombinant His-tagged protein expressed in E.coli · Mr: 54 kDa · PAF-AH catalyzes the hydrolysis of the acetyl group at the sn-2 position of PAF to yield lyso-PAF and acetate, thereby inactivating PAF. Two main types of PAF-AH have been characterized, namely the secreted (i.e., plasma) and intracellular enzymes. These are encoded on individual genes and share only 41% homology at the amino acid level.1,2 Plasma PAF-AH is a 45.4 kDa enzyme which is associated with the low-density lipoprotein fraction of plasma.3,4

1 Stafforini, D.M., McIntyre, T.M., Zimmerman, G.A., et al. Platelet-activating factor acetylhydrolases. J Biol Chem 272 17895-17898 (1997).

2 missing reference text

3 Tjoelker, L.W., Wilder, C., Eberhardt, C., et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374 549-553 (1995).

4 missing reference text

Synonyms
  • PAF-AH
  • Lp-PLA2
  • Platelet-activating Factor Acetylhydrolase
  • Lipoprotein PLA2
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Stafforini, D.M., McIntyre, T.M., Zimmerman, G.A., et al. Platelet-activating factor acetylhydrolases. J Biol Chem 272 17895-17898 (1997).

Tjoelker, L.W., Wilder, C., Eberhardt, C., et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374 549-553 (1995).

Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

Hattori, K., Adachi, H., Matsuzawa, A., et al. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. J Biol Chem 271 33032-33038 (1996).

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This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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PAF Acetylhydrolase (human recombinant)
PAF Acetylhydrolase Inhibitor Screening Assay Kit
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