See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

8-DY547-cGMP

Cayman Chemical Item Number 10010109

8-DY547-cGMP

See more

Description

Through activation by the binding of cyclic nucleotides, cyclic nucleotide-gated (CNG) ion channels mediate sensory signal transduction in photoreceptors and olfactory cells. 8-DY547-cGMP is a fluorescently-labeled cyclic nucleotide that can be used to study CNGA2 channel activation. 8-DY547-cGMP and cGMP open the channel with equal efficiency and control of the channel activity is rapid and reversible. The difference in fluorescence (ΔF) can be determined by using DY647.1

1 Biskup, C., Kusch, J., Schulz, E., et al. Relating ligand binding to activation gating in CNGA2 channels. Nature 446 440-443 (2007).

Formal Name 1-​ethyl-​2-​((4E)-​4-​(1-​ethyl-​3-​(4-​(2-​(methylthio)ethylamino)-​4-​oxobutyl)-​5-​sulfonatoindolin-​2-​ylidene)but-​2-​en-​2-​yl)-​3,​3-​dimethyl-​3H-​indolium-​5-​sulfonate-​guanosine-​3',​5'-​cyclic monophosphate,​ disodium salt
Molecular Formula C42H55N8O14PS3 · 2Na
Formula Weight 1069.1
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC[N+]​(C(C=C(S(=O)​([O-]​)​=O)​C=C1)​=C1C2(C)​C)​=C2/C=C/C=C3C(CCCC(NCCSC4NC(C(NC(N)​=N5)​=O)​C5N4C6OC(COP(O7)​([O-]​)​=O)​C7C6O)​=O)​(C)​C(C=C(S(=O)​([O-]​)​=O)​C=C8)​C8N/3CC.[Na+]​.[Na+]​

Background Reading

Biskup, C., Kusch, J., Schulz, E., et al. Relating ligand binding to activation gating in CNGA2 channels. Nature 446 440-443 (2007).
Size Price Quantity Subtotal
50 µg $122.00 $0.00
100 µg $232.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Cyclic GMP EIA Kit

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?