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AM1241

Cayman Chemical Item Number 10010118

(CAS 444912-48-5)

AM1241 (CAS 444912-48-5)

See more	Cannabinoids (296) Forensic Science (306) Neuroscience (654) Pain (144)

Description

AM1241 is a peripheral cannabinoid (CB₂) receptor agonist with a K_i value of 2 nM and greater than 100-fold selectivity over the central cannabinoid (CB₁) receptor in vitro.¹ AM1241 produces antinociception to thermal stimuli in rat hindpaw. The antinociceptive actions of AM1241 were blocked by the CB₂ receptor-selective antagonist AM630 but not by the CB₁ receptor-selective antagonist AM251 (Catalog No. 71670).¹

1 Malan, T.P., Ibrahim, M.M., Deng, H., et al. CB₂ cannabinoid receptor-mediated peripheral antinociception. Pain 93 239-245 (2001).

Formal Name	(2-iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone
CAS Number	444912-48-5
Molecular Formula	C₂₂H₂₂IN₃O₃
Formula Weight	503.3
Formulation	A crystalline solid
Purity	>97%
λ_max	249, 307 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(C1=CC([N+]([O-])=O)=CC=C1I)C2=CN(CC3N(C)CCCC3)C4=CC=CC=C42

Background Reading

Malan, T.P., Ibrahim, M.M., Deng, H., et al. CB₂ cannabinoid receptor-mediated peripheral antinociception. Pain 93 239-245 (2001).

AM1241 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$25.00		$0.00
5 mg	$65.00		$0.00
10 mg	$115.00		$0.00
25 mg	$260.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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AM694 Exclusive Potent synthetic CB	55.781724575096
RCS-4-C₄ homolog Exclusive Cannabimimetic similar to RCS-4	58.428009777551
AM630 A CB2 receptor antagonist	47.163132289748
Pravadoline A nonacidic anti-inflammatory	49.107296654389

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