Antigen: human sEH amino acids 292-306 (DMKGYGESSAPPEIE) · Host: rabbit · Application(s): WB; other applications not tested. · The metabolism of exogenous and endogenous epoxides relies in part upon the activity of soluble epoxide hydrolase (sEH).¹ The relevance of sEH to hypertension and inflammation makes it a potentially useful clinical drug target. Specifically, the conversion of epoxyeicosatrienoic acids (EpETrEs, EETs) by sEH to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs, DHETs) diminishes their vasodilator activity.² Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.^3,4 Cayman · s polyclonal antibody is useful for monitoring the quantity and distribution of sEH.

1 Halarnkar, P.P., Wixtrom, R.N., Silva, M.H., et al. Catabolism of epoxy fatty esters by the purified epoxide hydrolase from mouse and human liver. Arch Biochem Biophys 272 226-236 (1989).

2 Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).

3 Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

4 Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 102(28) 9772-9777 (2005).

Halarnkar, P.P., Wixtrom, R.N., Silva, M.H., et al. Catabolism of epoxy fatty esters by the purified epoxide hydrolase from mouse and human liver. Arch Biochem Biophys 272 226-236 (1989).

Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).

Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 102(28) 9772-9777 (2005).

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