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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Aspirin™ Effect-Detection Kit

Cayman Chemical Item Number 10010153

Aspirin™ Effect-Detection Kit

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Description

Millions of Americans ingest daily 'mini-dose' (80 mg) aspirin™ as a means of selectively inhibiting platelet cyclooxygenase-1 (COX-1) and subsequent production of Thromboxane A2 (TXA2). Recent studies indicate that a subpopulation of these users do not achieve the desired level of inhibition of TXA2, as determined by its more stable metabolites. The Cayman Aspirin™ Effect-Detection Kit is a 510K, clinically approved diagnostic kit for the measurement of 11-dehydro TXB2. It is intended to help physicians assess the effectiveness of their patients' aspirin™ regime, and to help identify the high-risk group who are inadequately controlled on an 80 mg aspirin™ dose. Current methods for detecting aspirin™ resistance include a number of blood-based assays that measure in vitro platelet aggregation. However, these methods are not quantitative and can be affected by factors that are unrelated to aspirin™ sensitivity. In order to more quickly and accurately detect aspirin™ resistance in at-risk patients, we have developed a rapid, quantitative competitive immunoassay for 11-dehydro TXB2 using a monoclonal antibody. This new assay can be completed in three hours and utilizes urine as the sample matrix. The assay exhibits intra-assay %CV values of <11% with sensitivity sufficient to detect the lower levels of 11-dehydro TXB2 in patients that respond well to aspirin™. Thus, this sensitive, urine-based monoclonal ELISA for 11-dehydro TXB2 detection combines the speed of the blood-based assays with the sensitivity and quantitation of the ELISA.
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Hamberg, M., Svensson, J., and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 72 2994-2998 (1975).

Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77 590-594 (1986).

Roberts, L.J., Sweetman, B.J., and Oates, J.A. Metabolism of thromboxane B2 in man. J Biol Chem 256(16) 8384-8393 (1981).

Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).

Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal Biochem 155 198-205 (1986).

Samuelsson, B., Granström, E., Green, K., et al. Prostaglandins. Annu Rev Biochem 44 669-695 (1975).

Ellis, E.F., Oelz, O., Roberts, L.J., et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193 1135-1137 (1976).

Salzman, P.M., Salmon, J.A., and Moncada, S. Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery. J Pharmacol Exp Ther 215 240-247 (1980).

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1 ea $604.00 $0.00
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This product is also available to buy in bulk quantities.

Please contact our Sales Department for a quote or to purchase.

  • All 480 well kits are supplied with a single 500 dtn vial of tracer and antiserum that must be used within the stated time following reconstitution.
  • Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

A 510(k) FDA-approved and CE-marked kit for human in vitro diagnostic use.

You may be eligible to receive a free sample Aspirin™ Effect-Detection Kit under the Cayman Challenge program.

Let Cayman analyze your samples for you. See EIA Service for details and availability.

Related Products

11-dehydro Thromboxane B2 EIA Kit - Monoclonal New

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