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NF-κB (p50) Western Ready Control

Cayman Chemical Item Number 10010184

Nuclear Factor-κB (p50); NF-κB1

See more	Nuclear Receptors (94) Proteins (209) Recombinant Proteins (198) Transcription Factors (24) Western Ready Control (27) Inflammation (396)

Description

Application(s): positive control for WB · Source: human recombinant protein expressed in E. coli · M_r: 74.5 kDa (GST-tagged), 48.5 kDa (native) · The NF-κB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-κB.¹ Members of this family are responsible for regulating over 150 target genes, including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. Because of this, NF-κB has often been called a 'central mediator of the human immune response'.² The most common Rel/NF-κB dimer in mammals contains p50-RelA (p50/p65) heterodimers and is specifically called NF-κB.

1 Gilmore, T.D. The Rel/NF-κB signal transduction pathway: Introduction. Oncogene 18 6842-6844 (1999).

2 Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18 6853-6866 (1999).

Synonyms	Nuclear Factor-κB (p50) NF-κB1
Purity	Whole cell lysate
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Gilmore, T.D. The Rel/NF-κB signal transduction pathway: Introduction. Oncogene 18 6842-6844 (1999).

Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18 6853-6866 (1999).

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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