ML-9 (CAS 105637-50-1) || Cayman Chemical

ML-9

Cayman Chemical Item Number 10010236

(CAS 105637-50-1)

ML-9 (CAS 105637-50-1)

Description

ML-9 was originally identified as a selective Ca2+-calmodulin-dependent myosin light chain kinase inhibitor. Concentrations from 10-100 µM are effective at inhibiting vascular smooth muscle tension and reducing intracellular Ca2+ concentrations.¹ ML-9 also inhibits PKB/Akt activity with an IC₅₀ range of 10-50 µM in rat primary adipocytes. This results in a specific inhibition of insulin-stimulated glucose transport and GLUT4/IGF II receptor translocation to the plasma membrane yet does not interfere with the antilipolytic effect of insulin.² Additionally, ML-9 inhibits other serine/threonine kinases including PKA (IC₅₀ = ~20 µM), p90 S6 (IC₅₀ = ~50 µM), and MAP kinase (IC₅₀ = ~35 µM).²

1 Ito, S., Kume, H., Honjo, H., et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis. Eur J Pharmacol 486 325-333 (2004).

2 Smith, U., Carvalho, E., Mosialou, E., et al. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun 268 315-320 (2000).

Formal Name

1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-1H-1,4-diazepine, monohydrochloride

CAS Number

105637-50-1

Molecular Formula

C₁₅H₁₇ClN₂O₂S · HCl

Formula Weight

361.3

Formulation

A crystalline solid

Purity

≥98%

λ_max

229, 300 nm

Stability

2 years

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

Copy SMILES to clipboard

ClC1=CC=CC2=C1C=CC=C2S(=O)(N3CCCN([H])CC3)=O.Cl

Background Reading

Ito, S., Kume, H., Honjo, H., et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis. Eur J Pharmacol 486 325-333 (2004).

Smith, U., Carvalho, E., Mosialou, E., et al. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun 268 315-320 (2000).

ML-9 is available in the following screening library:

Kinase Screening Library (96-Well)

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50 mg 
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100 mg 
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250 mg 
$506.00

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ML-9

ML-9 (CAS 105637-50-1)

Description

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ML-9

ML-9 (CAS 105637-50-1)

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