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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ML-9

Cayman Chemical Item Number 10010236

(CAS 105637-50-1)

ML-9 (CAS 105637-50-1)

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Description

ML-9 was originally identified as a selective Ca2+-calmodulin-dependent myosin light chain kinase inhibitor. Concentrations from 10-100 µM are effective at inhibiting vascular smooth muscle tension and reducing intracellular Ca2+ concentrations.1 ML-9 also inhibits PKB/Akt activity with an IC50 range of 10-50 µM in rat primary adipocytes. This results in a specific inhibition of insulin-stimulated glucose transport and GLUT4/IGF II receptor translocation to the plasma membrane yet does not interfere with the antilipolytic effect of insulin.2 Additionally, ML-9 inhibits other serine/threonine kinases including PKA (IC50 = ~20 µM), p90 S6 (IC50 = ~50 µM), and MAP kinase (IC50 = ~35 µM).2

1 Ito, S., Kume, H., Honjo, H., et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis. Eur J Pharmacol 486 325-333 (2004).

2 Smith, U., Carvalho, E., Mosialou, E., et al. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun 268 315-320 (2000).

Formal Name 1-​[(5-​chloro-​1-​naphthalenyl)sulfonyl]hexahydro-​1H-​1,​4-​diazepine,​ monohydrochloride
CAS Number 105637-50-1
Molecular Formula C15H17ClN2O2S · HCl
Formula Weight 361.3
Formulation A crystalline solid
Purity ≥98%
λmax 229, 300 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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ClC1=CC=CC2=C1C=CC=C2S(=O)​(N3CCCN([H]​)​CC3)​=O.Cl

Background Reading

Ito, S., Kume, H., Honjo, H., et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis. Eur J Pharmacol 486 325-333 (2004).

Smith, U., Carvalho, E., Mosialou, E., et al. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun 268 315-320 (2000).

ML-9 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $45.00 $0.00
50 mg $180.00 $0.00
100 mg $270.00 $0.00
250 mg $506.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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