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Olomoucine

Cayman Chemical Item Number 10010240

(CAS 101622-51-9)

Olomoucine (CAS 101622-51-9)

See more	Inhibitors (493) Cancer (606) Cell Cycle (71)

Description

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Olomoucine is a cdk inhibitor that acts by competing for the ATP binding site of the kinase. This purine derivative is an inhibitor for CDC2/cyclin B (IC₅₀ = 7 µM), CDK2/cyclin A (IC₅₀ = 7 µM), CDK2/cyclin E (IC₅₀ = 7 µM), CDK/p35 kinase (IC₅₀ = 3 µM), and ERK1/p44 MAP kinase (IC₅₀ = 25 µM).¹ Olomoucine inhibits DNA synthesis in interleukin-2 stimulated T lymphocytes, triggers G₁ arrest, and is also used to synchronize cells in G₁.² This inhibitor can attenuate astroglial proliferation and glial scar formation, decrease lesion cavity and mitigate functional deficits after spinal cord injury (SCI) in rats.³ Administration of olomoucine (3 mg/kg/day) to rats after SCI significantly suppressed microglial proliferation and proinflammatory cytokine expression, reduced tissue edema formation, and attenuated the number of apoptotic neurons.³

1 Veselý, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. Eur J Biochem 224 771-786 (1994).

2 Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol Cell 83(2) 105-120 (1995).

3 Tian, D., Xie, M., Yu, Z., et al. Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res 1135 177-185 (2007).

Formal Name	2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol
CAS Number	101622-51-9
Molecular Formula	C₁₅H₁₈N₆O
Formula Weight	298.3
Formulation	A crystalline solid
Purity	>98%
λ_max	209, 231, 290 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OCCNc1nc(NCc2ccccc2)c2ncn(C)c2n1

Background Reading

Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol Cell 83(2) 105-120 (1995).

Tian, D., Xie, M., Yu, Z., et al. Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res 1135 177-185 (2007).

Olomoucine is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$17.00		$0.00
5 mg	$77.00		$0.00
10 mg	$136.00		$0.00
25 mg	$298.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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