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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

AG-494

Cayman Chemical Item Number 10010242

(CAS 133550-35-3)

AG-494 (CAS 133550-35-3)

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Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation.1 AG-494 is an inhibitor of EGF receptor kinase with an IC50 value of 1 µM in HT-22 cells.2

1 Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32(10) 2344-2352 (1989).

2 Sagara, Y., Ishige, K., Tsai, C., et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem 277(39) 36204-36215 (2002).

Formal Name 2E-​cyano-​3-​(3,​4-​dihydroxyphenyl)-​N-​phenyl-​2-​propenamide
CAS Number 133550-35-3
Molecular Formula C16H12N2O3
Formula Weight 280.3
Formulation A crystalline solid
Purity >98%
λmax 370 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=C(O)​C=C(/C=C(C#N)​/C(NC2=CC=CC=C2)​=O)​C=C1

Background Reading

Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32(10) 2344-2352 (1989).

Sagara, Y., Ishige, K., Tsai, C., et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem 277(39) 36204-36215 (2002).

AG-494 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $27.00 $0.00
10 mg $51.00 $0.00
25 mg $122.00 $0.00
50 mg $216.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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