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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

U-83836E

Cayman Chemical Item Number 10010245

(CAS 137018-55-4)

U-83836E (CAS 137018-55-4)

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Description

U-83836E is an antioxidant which inhibits iron-dependent lipid peroxidation in rat brain with an IC50 value of 0.6 µM.1 This free radical scavenger has potent neuroprotective effects against ischemic injury and diabetic neuropathy.1,2 However at higher doses, U-83836E is highly cytotoxic. It reduces viability of rat brain endothelial cells (RBE4) with an IC50 value of 0.032 mM.3

1 Jacobsen, E.J., VanDoornik, F.J., Ayer, D.E., et al. 2-(aminomethyl) chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J Med Chem 35 4464-4472 (1992).

2 Sayyed, S.G., Kumar, A., and Sharma, S.S. Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. Life Sci 79 777-783 (2006).

3 Blasig, I.E., Mertsch, K., and Haseloff, R.F. Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier. Neuropharmacology 43 1006-1014 (2002).

Formal Name (2R)-​[[4-​(2,​6-​di-​1-​pyrrolidinyl-​4-​pyrimidinyl)-​1-​piperazinyl]methyl]-​3,​4-​dihydro-​2,​5,​7,​8-​tetramethyl-​2H-​1-​benzopyran-​6-​ol,​ hydrochloride
CAS Number 137018-55-4
Molecular Formula C30H44N6O2 · 2HCl
Formula Weight 593.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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Cc1c(C)​c2O[C@]​(C)​(CCc2c(C)​c1O)​CN1CCN(CC1)​c1cc(nc(n1)​N1CCCC1)​N1CCCC1

Background Reading

Sayyed, S.G., Kumar, A., and Sharma, S.S. Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. Life Sci 79 777-783 (2006).

Jacobsen, E.J., VanDoornik, F.J., Ayer, D.E., et al. 2-(aminomethyl) chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J Med Chem 35 4464-4472 (1992).

Blasig, I.E., Mertsch, K., and Haseloff, R.F. Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier. Neuropharmacology 43 1006-1014 (2002).
Size Price Quantity Subtotal
10 mg $12.00 $0.00
25 mg $29.00 $0.00
50 mg $54.00 $0.00
100 mg $96.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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