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SB 415286

Cayman Chemical Item Number 10010247

(CAS 264218-23-7)

SB 415286 (CAS 264218-23-7)

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Description

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis, and inflammation. SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. 1 As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 µM.1 SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway.2

1 Coghlan, M.P., Culbert, A.A., Cross, D.A.E., et al. Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7(10) 793-803 (2000).

2 Cross, D.A.E., Culbert, A.A., Chalmers, K.A., et al. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death. J Neurochem 77 94-102 (2001).

Formal Name 3-​[(3-​chloro-​4-​hydroxyphenyl)amino]-​4-​(2-​nitrophenyl)-​1H-​pyrrole-​2,​5-​dione
CAS Number 264218-23-7
Molecular Formula C16H10ClN3O5
Formula Weight 359.7
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1NC(=O)​C(=C1Nc1ccc(O)​c(Cl)​c1)​c1ccccc1[N]​(=O)​O

Background Reading

Coghlan, M.P., Culbert, A.A., Cross, D.A.E., et al. Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7(10) 793-803 (2000).

Cross, D.A.E., Culbert, A.A., Chalmers, K.A., et al. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death. J Neurochem 77 94-102 (2001).
Size Price Quantity Subtotal
500 µg $21.00 $0.00
1 mg $40.00 $0.00
5 mg $168.00 $0.00
10 mg $294.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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