Antigen: synthetic peptide from human cRBP7 amino acids 125-134 (QVCKQTFQRA) · Host: rabbit · Application(s): WB and IHC · Retinol is an essential micronutrient that plays a critical role in various physiological functions including cell growth and differentiation. Due to the instability and low solubility of retinol in the aqueous medium, it requires specific binding proteins in body fluids and within the cell for transport.¹ Cytoplasmic carriers of the retinol molecule, the cellular retinol-binding proteins (CRBPs), are monomeric proteins of about 15 kDa. cRBP7 is the most recently indentified cellular retinol carrier found to be expressed mainly in the kidney, heart, and transverse colon in humans.² In addition to the intracellular transport role of cRBR7, further study of this protein is warranted. Cayman · s cRBP7 polyclonal antibody detects both the mature protein at about 15 kDa by western blot in tissues/cells such as heart, HEK 293 cells, Cos-7 cells, and RAW 264.7 cells. The antibody can also be used for immunocytochemistry.

1 Noy, N. Retinoid-binding proteins: Mediators of retinoid action. Biochem J 348 481-495 (2000).

2 Folli, C., Calderone, V., Ramazzina, I., et al. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. J Biol Chem 277(44) 41970-41977 (2002).

Noy, N. Retinoid-binding proteins: Mediators of retinoid action. Biochem J 348 481-495 (2000).

Folli, C., Calderone, V., Ramazzina, I., et al. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. J Biol Chem 277(44) 41970-41977 (2002).