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Methyl-L-NIO (hydrochloride)

Cayman Chemical Item Number 10010252

(CAS 150403-96-6)

Methyl-L-NIO (hydrochloride) (CAS 150403-96-6)

See more	Inhibitors (493) Immunology (181) Inflammation (383) Nitric Oxide (101) Sepsis/Shock (22) Vascular Disease (103)

Description

Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive NOS inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (K_i = 3.0 µM) than eNOS (K_i = 10.0 µM) or iNOS (K_i = 9.5 µM).¹

1 Babu, B.R., and Griffith, O.W. N⁵-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

Formal Name	N5-(1-iminopropyl)-L-ornithine, monohydrochloride
CAS Number	150403-96-6
Molecular Formula	C₈H₁₉N₃O₂ · HCl
Formula Weight	225.7
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCC(=N)NCCCC(N)C(=O)

Background Reading

Babu, B.R., and Griffith, O.W. N⁵-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

Size	Price	Quantity	Subtotal
5 mg	$51.00		$0.00
10 mg	$97.00		$0.00
25 mg	$230.00		$0.00
50 mg	$408.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

L-NIL (hydrochloride)

L-Ornithine ¹³C (hydrochloride)

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