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Apigenin

Cayman Chemical Item Number 10010275

Versulin; NSC 83244; Flavone; Chamomile (CAS 520-36-5)

Apigenin (CAS 520-36-5)

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Description

Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.1 CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI 231 cells.2 Apigenin at 5 µM is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.3

1 Yamada, M., Katsuma, S., Adachi, T., et al. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci USA 102(21) 7736-7741 (2005).

2 Shen, J., Channavajhala, P., Seldin, D.C., et al. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IκBα1. J Immunol 167 4919-4925 (2001).

3 Raso, G.M., Meli, R., Di Carlo, G., et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 68 921-931 (2001).

Synonyms
  • Versulin
  • NSC 83244
  • Flavone
  • Chamomile
Formal Name 5,​7-​dihydroxy-​2-​(4-​hydroxyphenyl)-​4H-​1-​benzopyran-​4-​one
CAS Number 520-36-5
Molecular Formula C15H10O5
Formula Weight 270.2
Formulation A crystalline solid
Purity ≥98%
λmax 212, 269, 334 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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Oc1ccc(cc1)​c1cc(=O)​c2c(O)​cc(O)​cc2o1

Background Reading

Yamada, M., Katsuma, S., Adachi, T., et al. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci USA 102(21) 7736-7741 (2005).

Raso, G.M., Meli, R., Di Carlo, G., et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 68 921-931 (2001).

Shen, J., Channavajhala, P., Seldin, D.C., et al. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IκBα1. J Immunol 167 4919-4925 (2001).
Size Price Quantity Subtotal
25 mg $48.00 $0.00
50 mg $91.00 $0.00
100 mg $173.00 $0.00
500 mg $768.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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