Cayman Chemical | Apigenin | Description • Versulin; NSC 83244; Flavone; Chamomile (CAS 520-36-5)

10010275 Apigenin

Versulin; NSC 83244; Flavone; Chamomile (CAS 520-36-5)

Click image to enlarge

• See below for pricing and ordering

• See analysis tools

• See more Antioxidants; Flavonoids; Inhibitors; Inflammation; Nitric Oxide; Renal Disease

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC₅₀ value of 30 µM to improve renal function in a rat model of glomerulonephritis.¹ CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI 231 cells.² Apigenin at 5 µM is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E₂, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.³

1 Yamada, M., Katsuma, S., Adachi, T., et al. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci USA 102(21) 7736-7741 (2005).

2 Shen, J., Channavajhala, P., Seldin, D.C., et al. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IκBα1. J Immunol 167 4919-4925 (2001).

3 Raso, G.M., Meli, R., Di Carlo, G., et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 68 921-931 (2001).

	Download Product Insert 130 Kb PDF
	Download Material Safety Data Sheet (MSDS) 18 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 10010275 Apigenin

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.