1-Palmitoyl Lysophosphatidic Acid (sodium salt)

1-Palmitoyl Lysophosphatidic Acid (sodium salt) Exclusive

Cayman Chemical Item Number 10010290

1-Palmitoyl LPA

Description

1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.^1,2 In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+.³

1 Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278(28) 25600-25606 (2003).

2 Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends Cell Biol 4 213-219 (1994).

3 Krogfelt, K.A., Utley, M., Krivan, H.C., et al. Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosa. J Antimicrob Chemother 46(3) 377-384 (2000).

Synonyms

1-Palmitoyl LPA

Formal Name

1-palmitoyl-2-hydroxy-sn-glycero-3-phosphate, monosodium salt

Molecular Formula

C₁₉H₃₈O₇P · Na

Formula Weight

432.5

Formulation

A crystalline solid

Purity

>98%

Stability

2 years

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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CCCCCCCCCCCCCCCC(OC[C@@H](O)COP([O-])(O)=O)=O.[Na+]

Background Reading

Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278(28) 25600-25606 (2003).

Krogfelt, K.A., Utley, M., Krivan, H.C., et al. Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosa. J Antimicrob Chemother 46(3) 377-384 (2000).

Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions. Trends Cell Biol 4 213-219 (1994).

1-Palmitoyl Lysophosphatidic Acid (sodium salt) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

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Subtotal

1 mg 
$31.00

$0.00

5 mg 
$140.00

$0.00

10 mg 
$248.00

$0.00

25 mg 
$543.00

$0.00

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1-Palmitoyl Lysophosphatidic Acid (sodium salt) Exclusive