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CAY10554

Cayman Chemical Item Number 10010301

BML-259 (CAS 267654-00-2)

CAY10554 (CAS 267654-00-2)

See more	Inhibitors (493) Cancer (606) Cell Cycle (71)

Description

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and neurodegenerative diseases. CAY10554 is a potent inhibitor of Cdk5 and Cdk2, with IC₅₀ values of 64 and 98 nM, respectively.¹

1 Helal, C.J., Sanner, M.A., Cooper, C.B., et al. Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease. Bioorg Med Chem Lett 14 5521-5525 (2004).

Synonyms	BML-259
Formal Name	N-[5-(1-methylethyl)2-thiazolyl]-benzeneacetamide
CAS Number	267654-00-2
Molecular Formula	C₁₄H₁₆N₂OS
Formula Weight	260.4
Formulation	A crystalline solid
Purity	>95%
λ_max	275 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(Cc1ccccc1)Nc1ncc(s1)C(C)C

Background Reading

Helal, C.J., Sanner, M.A., Cooper, C.B., et al. Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease. Bioorg Med Chem Lett 14 5521-5525 (2004).

Size	Price	Quantity	Subtotal
5 mg	$51.00		$0.00
10 mg	$97.00		$0.00
25 mg	$230.00		$0.00
50 mg	$408.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Downloads

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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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