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AG-213

Cayman Chemical Item Number 10010314

Tyrphostin AG-213; Tyrphostin 47 (CAS 122520-86-9)

AG-213 (CAS 122520-86-9)

See more	Inhibitors (493) Cancer (606)

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation.¹ AG-213 is an inhibitor of EGF receptor kinase with an IC₅₀ value of 2.4 µM in the human epidermoid carcinoma cell line A431.¹

1 Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32(10) 2344-2352 (1989).

Synonyms	Tyrphostin AG-213 Tyrphostin 47
Formal Name	2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenethioamide
CAS Number	122520-86-9
Molecular Formula	C₁₀H₈N₂O₂S
Formula Weight	220.2
Formulation	A crystalline solid
Purity	>97%
λ_max	249, 323, 392 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N#C/C(=C\c1ccc(O)c(O)c1)/C(=S)N

Background Reading

Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32(10) 2344-2352 (1989).

AG-213 is available in the following screening library:

Kinase Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$45.00		$0.00
10 mg	$86.00		$0.00
25 mg	$203.00		$0.00
50 mg	$360.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

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