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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Harmine

Cayman Chemical Item Number 10010324

(CAS 442-51-3)

Harmine (CAS 442-51-3)

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Description

Peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs.1 Harmine is a β-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARγ expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.2 Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNFα, IL-1β, iNOS) and macrophage accumulation in adipose tissue.2

1 Hauner, H. The mode of action of thiazolidinediones. Diabetes Metab Res Rev 18 S10-S15 (2002).

2 Waki, H., Park, K.W., Mitro, N., et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metab 5 357-370 (2007).

Formal Name 7-​methoxy-​1-​methyl-​9H-​pyrido[3,​4-​b]indole
CAS Number 442-51-3
Molecular Formula C13H12N2O
Formula Weight 212.1
Formulation A crystalline solid
Purity ≥98%
λmax 242, 302 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc2c(c1)​[nH]​c1c(C)​nccc21

Background Reading

Waki, H., Park, K.W., Mitro, N., et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metab 5 357-370 (2007).

Hauner, H. The mode of action of thiazolidinediones. Diabetes Metab Res Rev 18 S10-S15 (2002).

Harmine is available in the following screening library:

Size Price Quantity Subtotal
250 mg $16.00 $0.00
500 mg $30.00 $0.00
1 g $58.00 $0.00
5 g $256.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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