Cayman Chemical | HDBA | Description • Lavendustin C; NSC 666251 (CAS 125697-93-0)

10010329 HDBA

Lavendustin C; NSC 666251 (CAS 125697-93-0)

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HDBA, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC₅₀ value of 0.012 µM.¹ HDBA also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC₅₀ values of 0.5 and 0.2 µM, respectively.² At a concentration of 10-150 µM, HDBA inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.³

1 Onoda, T., Iinuma, H., Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod 52(6) 1252-1257 (1989).

2 O'Dell, T.J., Kandel, E.R., Grant, S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558-560 (1991).

3 Burt, H.M., Jackson, J.K., Salari, H. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. J Leukoc Biol 55 112-119 (1994).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.