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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Lavendustin C

Cayman Chemical Item Number 10010329

HDBA; NSC 666251 (CAS 125697-93-0)

Lavendustin C (CAS 125697-93-0)

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Description

HDBA, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM.1 HDBA also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 µM, respectively.2 At a concentration of 10-150 µM, HDBA inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.3

1 Onoda, T., Iinuma, H., Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod 52(6) 1252-1257 (1989).

2 O'Dell, T.J., Kandel, E.R., and Grant, S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558-560 (1991).

3 Burt, H.M., Jackson, J.K., and Salari, H. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. J Leukoc Biol 55 112-119 (1994).

Synonyms
  • HDBA
  • NSC 666251
Formal Name 5-​[[(2,​5-​dihydroxyphenyl)methyl]amino]-​2-​hydroxy-​benzoic acid
CAS Number 125697-93-0
Molecular Formula C14H13NO5
Formula Weight 275.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1ccc(O)​c(CNc2ccc(O)​c(c2)​C(=O)​O)​c1

Background Reading

Onoda, T., Iinuma, H., Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod 52(6) 1252-1257 (1989).

Burt, H.M., Jackson, J.K., and Salari, H. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. J Leukoc Biol 55 112-119 (1994).

O'Dell, T.J., Kandel, E.R., and Grant, S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558-560 (1991).

Lavendustin C is available in the following screening library:

Size Price Quantity Subtotal
1 mg $20.00 $0.00
5 mg $90.00 $0.00
10 mg $160.00 $0.00
50 mg $700.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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