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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Fluvastatin (sodium salt)

Cayman Chemical Item Number 10010337

(CAS 93957-55-2)

Fluvastatin (sodium salt) (CAS 93957-55-2)

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Description

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Fluvastatin acts as a competitive inhibitor of HMG-CoA reductase with respect to binding of the substrate HMG-CoA (Ki = 0.3 nM) but not with respect to binding of NADPH.2,3 It is marketed under the trade name Lescol for the treatment of hypercholesterolemia in the prevention of cardiovascular disease. When fluvastatin was administered in a clinical trial to patients undergoing percutaneous coronary intervention, LDL cholesterol levels were reduced by 27% after six weeks of treatment with a dose of 40 mg/kg twice a day compared to placebo.4

1 Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2 517-526 (2003).

2 Istvan, E.S., and Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160-1164 (2001).

3 Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res 31(1) 9-27 (1995).

4 Serruys, P.W.J.C., de Feyter, P., Macaya, C., et al. Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: A randomized controlled trial. JAMA 287(24) 3215-3222 (2002).

Formal Name 7-​[3-​(4-​fluorophenyl)-​1-​(1-​methylethyl)-​1H-​indol-​2-​yl]-​3,​5-​dihydroxy-​6-​heptenoic acid,​ sodium salt
CAS Number 93957-55-2
Molecular Formula C24H25FNO4 · Na
Formula Weight 433.5
Formulation A crystalline solid
Purity ≥98%
λmax 233, 305 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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[Na]​.OC(=O)​CC(O)​CC(O)​/C=C/c1c(c2ccc(F)​cc2)​c2ccccc2n1C(C)​C

Background Reading

Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2 517-526 (2003).

Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res 31(1) 9-27 (1995).

Serruys, P.W.J.C., de Feyter, P., Macaya, C., et al. Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: A randomized controlled trial. JAMA 287(24) 3215-3222 (2002).

Istvan, E.S., and Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160-1164 (2001).

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Size Price Quantity Subtotal
10 mg $20.00 $0.00
25 mg $44.00 $0.00
50 mg $66.00 $0.00
100 mg $118.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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