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Pravastatin (sodium salt)

Cayman Chemical Item Number 10010343

(CAS 81131-70-6)

Pravastatin (sodium salt) (CAS 81131-70-6)

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Description

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.2 It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.2 Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.2

1 Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2 517-526 (2003).

2 Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res 31(1) 9-27 (1995).

Formal Name 1S,​2S,​6S,​7S,​8R,​8aR-​hexahydro-​βR,​δR,​6-​trihydroxy-​2-​methyl-​8-​[(2S)-​2-​methyl-​1-​oxobutoxy]-​1-​naphthaleneheptanoic acid,​ monosodium salt
CAS Number 81131-70-6
Molecular Formula C23H35O7 · Na
Formula Weight 446.5
Formulation A crystalline solid
Purity ≥98%
λmax 238 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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[Na]​.CC[C@H]​(C)​C(=O)​OC1C[C@H]​(O)​C=C2C=C[C@H]​(C)​[C@H]​(CCC(O)​CC(O)​CC(=O)​O)​[C@@H]​12

Background Reading

Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2 517-526 (2003).

Corsini, A., Maggi, F.M., and Catapano, A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res 31(1) 9-27 (1995).
Size Price Quantity Subtotal
5 mg $11.00 $0.00
10 mg $21.00 $0.00
25 mg $50.00 $0.00
50 mg $88.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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