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CCG-1423

Cayman Chemical Item Number 10010350

(CAS 285986-88-1)

CCG-1423 (CAS 285986-88-1)

See more	Inhibitors (493) Cancer (606) Signal Transduction (314)

Description

The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription.¹ It inhibits SRF-driven luciferase expression in PC-3 cells following stimulation with constitutively active Gα13 with an IC₅₀ value of 1 µM. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-1423 selectively inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.¹

1 Evelyn, C.R., Wade, S.M., Wang, Q., et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther 6(8) 2249-2260 (2007).

Formal Name	N-[2-[4(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-benzamide
CAS Number	285986-88-1
Molecular Formula	C₁₈H₁₃ClF₆N₂O₃
Formula Weight	454.8
Formulation	A crystalline solid
Purity	>98%
λ_max	249 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Clc1ccc(cc1)NC(=O)C(C)ONC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

Background Reading

Evelyn, C.R., Wade, S.M., Wang, Q., et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther 6(8) 2249-2260 (2007).

Size	Price	Quantity	Subtotal
5 mg	$30.00		$0.00
10 mg	$57.00		$0.00
25 mg	$135.00		$0.00
50 mg	$240.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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