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10010364 FABP5 (human recombinant)
Keratinocyte FABP; Psoriasis-Associated FABP; Fatty Acid Binding Protein 5; Epidermal-FABP; E-FABP; DA11 FABP
FABP5 (human recombinant) Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Source:
recombinant N-terminal hexahistidine-tagged protein expressed in E. coli
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Mr:
18 kDa
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Fatty acid binding protein 5 (FABP5) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.1 Members of this protein family exhibit high affinity for lipophilic ligands and were named according to the tissue from which they were initially isolated.1 FABP5 is found in skin, brain, lens, capillary epithelium, and retina. Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.2 FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. The presence of one or more disulphide bridges is a unique feature of FABP5 that may be physiologically relevant.2 Elevated levels of FABP5 have been observed in prostate and bladder carcinoma.1
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1
Zimmerman, A.W., Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).
2
Massolini, G., Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).
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Purchase 10010364 FABP5 (human recombinant)
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-13.
Prices are subject to change without notice.
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