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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

FABP5 (human recombinant)

Cayman Chemical Item Number 10010364

Keratinocyte FABP; Psoriasis-Associated FABP; Fatty Acid Binding Protein 5; Epidermal-FABP; E-FABP; DA11 FABP

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Description

Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli · Mr: 18 kDa · Fatty acid binding protein 5 (FABP5) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.1 Members of this protein family exhibit high affinity for lipophilic ligands and were named according to the tissue from which they were initially isolated.1 FABP5 is found in skin, brain, lens, capillary epithelium, and retina. Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.2 FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. The presence of one or more disulphide bridges is a unique feature of FABP5 that may be physiologically relevant.2 Elevated levels of FABP5 have been observed in prostate and bladder carcinoma.1

1 Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).

2 Massolini, G., and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).

Synonyms
  • Keratinocyte FABP
  • Psoriasis-Associated FABP
  • Fatty Acid Binding Protein 5
  • Epidermal-FABP
  • E-FABP
  • DA11 FABP
Formulation A solution in 50 mM sodium phosphate, pH 7.2, containing 20% glycerol and 100 mM sodium chloride
Purity >95%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).

Massolini, G., and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).
Size Price Quantity Subtotal
25 µg $99.00 $0.00
50 µg $188.00 $0.00
100 µg $356.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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