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GW 842166X

Cayman Chemical Item Number 10010372

(CAS 666260-75-9)

GW 842166X (CAS 666260-75-9)

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Description

The peripheral cannabinoid (CB2) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ9-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand.1 GW 842166X is a CB2 receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively.2 When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.2

1 Khanolkar, A.D., Lu, D., Ibrahim, M., et al. Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem 50 6493-6500 (2007).

2 Giblin, G.M.P., O'Shaughnessy, C.T., Naylor, A., et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem 50(11) 2597-2600 (2007).

Formal Name 2-​[(2,​4-​dichlorophenyl)amino]-​N-​[(tetrahydro-​2H-​pyran-​4-​yl)methyl]-​4-​(trifluoromethyl)-​5-​pyrimidinecarboxamide
CAS Number 666260-75-9
Molecular Formula C18H17Cl2F3N4O2
Formula Weight 449.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Clc1ccc(Nc2ncc(C(=O)​NCC3CCOCC3)​c(n2)​C(F)​(F)​F)​c(Cl)​c1

Background Reading

Khanolkar, A.D., Lu, D., Ibrahim, M., et al. Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem 50 6493-6500 (2007).

Giblin, G.M.P., O'Shaughnessy, C.T., Naylor, A., et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem 50(11) 2597-2600 (2007).
Size Price Quantity Subtotal
1 mg $21.00 $0.00
5 mg $95.00 $0.00
10 mg $168.00 $0.00
25 mg $368.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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