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10010398 CB13
(CAS 432047-72-8)
CB13 Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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CB13 is a dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors.1 In rats, oral CB13 (3 mg/kg) potently blocks CB1-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability.1 CB13 does not possess genotoxic potential, as indicated by negative results in both chromosome aberration and reverse mutation assays.1 The effects of CB13 on other aspects of CB signaling have not been assessed.
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1
Dziadulewicz, E.K., Bevan, S.J., Brain, C.T., et al. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem 50 3851-3856 (2007).
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Pricing updated 2010-03-12.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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