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CB-13

Cayman Chemical Item Number 10010398

CRA-13 (CAS 432047-72-8)

CB-13 (CAS 432047-72-8)

See more	Cannabinoids (296) Forensic Science (306) Inflammation (383) Neuroscience (654) Pain (144)

Description

CB-13 is a dual agonist of the CB₁ (IC₅₀ = 15 nM) and CB₂ (IC₅₀ = 98 nM) receptors.¹ In rats, oral CB-13 (3 mg/kg) potently blocks CB₁-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability.¹ CB-13 does not possess genotoxic potential, as indicated by negative results in both chromosome aberration and reverse mutation assays.¹ The effects of CB-13 on other aspects of CB signaling have not been assessed.

1 Dziadulewicz, E.K., Bevan, S.J., Brain, C.T., et al. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A potent, orally bioavailable human CB₁/CB₂ dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem 50 3851-3856 (2007).

Synonyms	CRA-13
Formal Name	1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone
CAS Number	432047-72-8
Molecular Formula	C₂₆H₂₄O₂
Formula Weight	368.5
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCOc1ccc(c2ccccc12)C(=O)c1cccc2ccccc12

Background Reading

Dziadulewicz, E.K., Bevan, S.J., Brain, C.T., et al. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A potent, orally bioavailable human CB₁/CB₂ dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem 50 3851-3856 (2007).

CB-13 is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$43.00		$0.00
10 mg	$82.00		$0.00
25 mg	$194.00		$0.00
50 mg	$344.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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